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Bioprinting 101 Part 9 – Decellularized Extracellular Matrices

Written by David

March 11, 2019

Today we will be learning about one of the more complex sounding materials within bioprinting. Decellularized extracellular matrices are important within bioprinting processes. That term itself seems like a mouthful. Do not fret. We will break it down into simple parts, and it will be manageable to understand. Firstly let us define what it means to be decellularized. Decellularization is the process used in biomedical engineering to isolate the extracellular matrix (ECM) of tissue from its inhabiting cells, leaving an ECM scaffold of the original tissue, which can be used in artificial organ and tissue regeneration. The extracellular matrix is a three-dimensional network of extracellular macromolecules, such as collagen, enzymes, and glycoproteins, that provide structural and biochemical support of surrounding cells. The composition of an ECM varies between multicellular structures. Typically cell to cell communication occurs within an ECM, as well as cell differentiation. Cell differentiation refers to the […]

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